Power of Attorney for Owen Hughes

This filing relates to a Power of Attorney granted by Owen Hughes, a director of AnaptysBio, Inc., to Daniel Faga and Dave McKeon. The power of attorney authorizes the attorneys-in-fact to execute and file all necessary Form 3, 4, or 5 reports with the SEC and any stock exchange on behalf of Mr. Hughes, in accordance with Section 16(a) of the Securities Exchange Act of 1934. This authorization covers any transactions in the company's securities. The power of attorney remains effective until Mr. Hughes is no longer required to file such reports, or until it is revoked in writing. The document also clarifies that neither the attorneys-in-fact nor the company are assuming Mr. Hughes' compliance responsibilities under Section 16.