Form 4 Filing for Paul F. Lizzul

Paul F. Lizzul, Chief Medical Officer of ANAPTYSBIO, INC, reported several transactions on December 22, 2025. Lizzul acquired 1,500 shares of Common Stock under the Company's ESPP at a price of $18.5 per share, increasing his post-transaction holdings to 28,467 shares. Concurrently, Lizzul disposed of 1,500 shares of Common Stock at $50.0 per share, resulting in 26,967 shares remaining. This sale was executed under a Rule 10b5-1 trading plan. Additionally, Lizzul exercised an employee stock option for 1,500 shares of Common Stock at a price of $0.0, with the option having a strike price of $18.5 and an expiration date of July 29, 2030. Following this, his post-transaction shares for this option are 83,500. It is noted that Lizzul holds further vested options for an additional 394,810 shares.