Form 3 Filing for ACHIEVE LIFE SCIENCES, INC.

This filing reports initial beneficial ownership of securities for TPG GP A, LLC, James G. Coulter, and Jon Winkelried (collectively, the "Reporting Persons") in ACHIEVE LIFE SCIENCES, INC. (ACHV). TPG Auriga, an entity controlled by the Reporting Persons, directly holds 6,877,580 shares of Common Stock and 6,877,580 warrants. Each warrant is exercisable for one share of Common Stock at an exercise price of $3.51, subject to adjustments. The warrants become exercisable after April 17, 2026, and expire twenty business days after FDA approval of cytisinicline for smoking cessation, with specific conditions regarding share availability and beneficial ownership limits. The Reporting Persons disclaim beneficial ownership beyond their pecuniary interests.